Mouse Agtr1a Stable Cell Line - CHO-K1

Mouse Agtr1a, also known as angiotensin II receptor type 1, is a receptor protein encoded by the mouse Agtr1a gene. This gene is part of the angiotensin receptor family, and the protein it encodes plays a key role in the renin-angiotensin system, helping to regulate blood pressure and fluid balance in the body. Once this receptor is activated, it stimulates various intracellular pathways, leading to physiological responses such as vasoconstriction, aldosterone synthesis and secretion, increased vasopressin secretion, cardiac hypertrophy, and extracellular matrix synthesis. Defects in the Agtr1a gene can lead to various health-related problems, such as hypertension, vascular remodeling, inflammation, and end-organ damage. Therefore, the Agtr1a gene and its protein product play an important role in maintaining cardiovascular homeostasis. It may become an effective target for the treatment of cardiovascular diseases.

CHO-K1 cells are widely used cell lines in biology, and they can be genetically modified to produce a variety of protein products. This CHO-K1 cell line has been modified to stably express the mouse Agtr1a receptor. By introducing the gene encoding the receptor into CHO-K1 cells, the cells were able to produce the receptor and present it on their cell surface.