Transfected Stable Cell Lines
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Cat. No. : VLP-0009
| Cat. No. | VLP-0009 |
| Description | Non-infectious Mayaro Virus-Like Particles consist of E1, E2 and capsid proteins without genome. The VLPs are produced in HEK293 cells. |
| Storage | -80˚C |
| Shipping | Dry ice |
Mayaro virus is an enveloped virus and has an icosahedral capsid with a diameter of 70 nm. The virus genome is composed of a linear, positive-sense, single-stranded RNA with 11,429 nucleotides, excluding the 5’ cap nucleotide and 3’ poly(A) tail. The virus RNA genome contains the 5' untranslated region, 3' noncoding region, and two open reading frames (ORFs). The 5’-proximal ORF codes for a polyprotein that after cleavage forms nonstructural proteins (nsP1, nsP2, nsP3, nsP4) and the 3’-proximal ORF with a 26S promoter codes for a polyprotein that is cleaved into structural proteins to generate capsid proteins and envelope surface glycoproteins (E1, E2, E3, C, 6K).
A: Mayaro virus (MAYV) is a positive-sense single stranded RNA virus that belongs to the genus Alphavirus, a member of the Togaviridae family of viruses. It is a member of the Semliki Forest antigenic sero-complex, a serological group within the Alphavirus genus, and is closely related to Chikungunya virus
A: At Creative Biogene, we have prepared recombinant Mayaro Virus VLP utilising our proprietary mammalian cell expression system. These particles contain Capsid and E1 and E2 envelope proteins. They will find application for researchers and assay developers who are looking to develop assays to distinguish Mayaro virus infection from Chikugunya virus.
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The quality of the particles was excellent, and they were easy to work with. I highly recommend this product to fellow researchers looking to study Mayaro virus.
The detailed protocols provided by the manufacturer were extremely helpful, making it easy to integrate the particles into our experimental workflow. I am highly impressed with this product and its performance and would definitely purchase it again.
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