LXR-Luc Stable Cell Line - THP1

Name: LXR-Luc Stable Cell Line - THP1
SKU: CSC-RR01268
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RR01268

Host Cell : THP1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Documents

Cat. No.	CSC-RR01268
Description	This cell line is engineered to stably express luciferase reporter gene under the control of LXR response element.
Target Gene	LXR-Luc
Host Cell	THP1
Host Cell Species	Homo sapiens (Human)
Applications	This cell line contains the LXR-responsive luciferase reporter construct, allowing quantitative measurement of endogenous LXR transcriptional activity via luminescence readout. Identification of LXR agonists and antagonists Screen small molecule compounds to detect ligands that activate or inhibit LXR transcriptional function for drug discovery. Characterization of LXR signaling pathway regulators Evaluate how overexpression or knockdown of target genes modulates LXR-mediated transcription. Study of lipid metabolism regulation Assess the impact of fatty acids, oxysterols and other lipid metabolites on LXR activation, which governs cholesterol efflux and lipid homeostasis. Evaluation of natural product bioactivity Test extracts and natural compounds for potential LXR-modulating effects in metabolic research. Mechanism research of metabolic and inflammatory diseases Investigate LXR-related signaling alterations under inflammatory, atherosclerotic or hepatic steatosis conditions. High-throughput compound screening Enable automated luminescence detection for large-scale pharmaceutical screening targeting lipid metabolic disorders.
Size	One vial of frozen cells, typically >1x10^6cells/vial
Stability	This cell line is stable at least 10 passages.
Quality Control	Cell luciferase assay Mycoplasma detection.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Suspension cell line

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

CSC-RR01268-LXR-Luc Stable Cell Line - THP1-Datasheet

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