Human CLDN18-A2 Virus-Like Particles

Claudin-18.2 (CLDN18-A2) is a member of the claudin family, a group of integral membrane proteins that are essential for the formation and function of tight junctions in epithelial and endothelial cell layers. These tight junctions play a crucial role in maintaining tissue integrity by regulating the passage of ions, molecules, and water between cells. CLDN18-A2 is primarily expressed in gastric epithelial cells, where it participates in the maintenance of tight junctions that are essential for the barrier function of the gastric wall. This protein has attracted considerable attention in cancer research due to its restricted expression pattern and its role in various malignancies, especially gastric cancer. Advances in molecular biology and immunohistochemistry have shown that CLDN18-A2 is overexpressed in several gastrointestinal cancers, including gastric adenocarcinoma and pancreatic cancer, making it a promising target for therapeutic intervention. Human CLDN18-A2 virus-like particles (VLPs) represent a cutting-edge advance in the field of immunotherapy and vaccine development. VLPs are molecular mimics of viruses that provide an effective platform for presenting antigens to the immune system, resulting in a potent immunogenic response. Structurally intact human Claudin-18.2 VLPs are designed to present the CLDN18-A2 protein in its native conformation, retaining the structural and functional integrity necessary to elicit an appropriate immune response. These VLPs lack viral genetic material, ensuring they are non-infectious and safe. They mimic the external morphology of the natural virus, thereby effectively stimulating the host's immune system without the risk of actual viral infection.