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Human CLDN18-A2-GFP Virus-Like Particles

For research use only. Not intended for any clinical use.

Cat. No. :   VLP-N-00024

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Product Information

Cat. No. VLP-N-00024
Description Virus-Like Particles that contain structurally intact fusion protein of Human Claudin-18.2 and GFP, designed for antibody screening and ligand binding assays etc.
Gene Abbr CLDN18-A2-GFP
Applications Human CLDN18-A2-GFP virus-like particles (VLPs) have a variety of potential applications in research and medical science. Cancer Research: Claudin 18, particularly its isoform A2, has been implicated in a variety of cancers, including gastric, pancreatic, and lung cancers. VLPs containing CLDN18-A2-GFP can be used to study the expression, localization, and function of this protein in cancer cells. This can help identify therapeutic targets and understand the mechanisms of cancer progression. Therapeutic Screening: These VLPs can be used to screen for potential therapeutic agents. For example, they can help identify molecules or antibodies that specifically bind to or inhibit the function of CLDN18-A2, which could be potential candidates for drug development. Vaccine Development: VLPs are frequently used in vaccine research due to their ability to mimic the structure of viruses without being infectious. CLDN18-A2-GFP VLPs can be used to develop cancer vaccines, in which the immune system is trained to recognize and attack cells expressing the CLDN18-A2 protein. Imaging and Localization Studies: The GFP tag enables visualization of the VLPs in living cells or tissue samples. This is particularly useful for tracking the expression and localization of CLDN18-A2 in various cell types and under different conditions. Basic Cell and Molecular Biology: These VLPs can be used in basic research to understand the role of CLDN18-A2 in cell biology, particularly in the formation and maintenance of tight junctions in epithelial cells. This knowledge can form the basis for a variety of applications in disease research and tissue engineering.
Storage -80˚C
Shipping Dry ice
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CLDN18-A2 refers to isoform 2 of Claudin-18 (CLDN18), a protein that belongs to the claudin family. Claudins are integral membrane proteins that play a key role in the formation and maintenance of tight junctions, a structure that helps cells within tissues adhere to each other and establish a selectively permeable barrier. This isoform is important for the integrity and function of the gastric epithelial barrier, helping the stomach to accommodate and process food, resist pathogen invasion, and protect underlying tissues from irritating gastric contents such as hydrochloric acid and digestive enzymes. Alterations or dysregulation of CLDN18-A2 have been associated with various pathologies, including gastric cancer. Therefore, CLDN18-A2 is considered a potential biomarker and therapeutic target for certain gastric diseases and cancers.

Virus-like particles (VLPs) represent an advanced approach in the fields of biotechnology and immunology, providing a promising platform for vaccine development, targeted drug delivery, and molecular imaging. Human CLDN18-A2-GFP VLPs vividly demonstrate the potential of this innovative technology. These VLPs encapsulate the structural integrity of CLDN18.2 protein fused to green fluorescent protein (GFP), thereby facilitating advanced studies and applications related to cancer biology, particularly in gastric and pancreatic adenocarcinomas where CLDN18.2 is highly expressed.

Customer Q&As
What exactly are human CLDN18-A2-GFP virus-like particles?

A: Human CLDN18-A2-GFP virus-like particles are artificially created structures that mimic the appearance of a virus and contain the CLDN18-A2 protein fused with green fluorescent protein (GFP). These particles are utilized in research to study the behavior and interaction of CLDN18-A2 protein in cells.

What is the significance of studying human CLDN18-A2-GFP virus-like particles?

A: Studying human CLDN18-A2-GFP virus-like particles helps researchers to understand the behavior and function of the CLDN18-A2 protein in a controlled environment. The use of GFP allows for easy visualization and tracking of these particles in live cells, enabling researchers to study its localization, movement, and interactions with other cellular components. This knowledge can contribute to a better understanding of CLDN18-A2's role in various cellular processes or disease states.

Are human CLDN18-A2-GFP virus-like particles considered harmful to humans?

A: No, human CLDN18-A2-GFP virus-like particles are not infectious or harmful to humans. They do not contain a complete viral genome and lack the ability to replicate. These particles are solely used as research tools and do not pose a threat to human health.

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Customer Reviews
Exceptional Quality

I found the Human CLDN18-A2-GFP Virus-Like Particles to be highly effective for my research. The particles displayed exceptional quality and were user-friendly. I would highly recommend them for scientific studies.

United States

Easy to Use

The Human CLDN18-A2-GFP Virus-Like Particles have been instrumental in advancing my research. The particles exhibited high purity and stability, ensuring accurate and reproducible results. An excellent product overall!

United States

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