human UBE2K ORF clone (NM_001111113.1)

Name: human UBE2K ORF clone (NM_001111113.1)
SKU: CDCH097302
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCH097302

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Product Information

Gene Information

Cat. No.	CDCH097302
Description	Homo sapiens ubiquitin-conjugating enzyme E2K (UBE2K), transcript variant 3, mRNA.
Product Type	ORF clone
Gene Abbr	UBE2K
Species	Human
ORF Size	450bp
Format	purified plasmid or bacterial stock
Vector	pDONR
Warning	Please note that the protein for this clone has been annotated or predicted in the UNIPROT database to have a signal peptide. Placing a tag at the N-terminus of this protein may result in loss of the signal peptide function.

Target Gene

UBE2K

Background

The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

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