HPV45-Luciferase Reporter Pseudovirus

Human papillomavirus (HPV) is a non-enveloped DNA virus from the papillomavirus family. Over 200 types have been described and many are carcinogenic. More than 10 HPV types (including types 16, 18, 31, and 45) are called "high-risk" types because persistent infection has been linked to many cancers. The HPV genome is approximately 8 kb in length and is replicated in the nucleus. It encodes viral proteins that is required for completion of the virus life cycle. The capsid of HPV is composed of major capsid protein (L1) and Minor capsid protein (L2) which can form virions by self-assembly. HPV pseudoviruses are synthetic viruses that contain L1, L2 proteins and non-viral DNA, and have been widely used in HPV research.