GFP/Luc Reporter Cell Line - KU-812E

The GFP/Luc Reporter Cell Line - KU-812E is a powerful tool in a variety of research applications in the field of cell and molecular biology. The following are the main applications of this versatile cell line: Gene expression studies: GFP and luciferase reporters allow real-time monitoring of gene expression. Researchers can quantify GFP and luciferase activity levels to assess the transcriptional activity of a specific gene or promoter under different conditions. Drug screening and discovery: The GFP/Luc Reporter Cell Line - KU-812E is very valuable in high-throughput screening (HTS) of pharmaceutical agents. Researchers can use GFP and Luc reporters to identify compounds that modulate gene expression, providing insight into potential therapeutic candidates. Signal transduction studies: The KU-812E cell line can be used to study signaling pathways. By linking GFP and luciferase reporters to specific response elements, researchers can study how different signaling molecules or conditions affect pathway activity. Functional genomics: The dual reporter system allows the study of gene regulatory elements and their interactions. This cell line can be used in experiments involving gene knockout, overexpression, or CRISPR/Cas9-mediated gene editing to analyze gene function and regulation. Cancer research: KU-812E cells can be used to study the mechanisms of leukemogenesis as they are derived from megakaryocytic leukemia. The reporter system helps track the response of cells to oncogenes, tumor suppressors, and potential anticancer drugs. Toxicology studies: The GFP/Luc reporter system provides a sensitive and non-invasive method to assess the cytotoxicity of environmental toxins, drugs, or other chemical compounds, making it a valuable tool for safety assessments.