GFP/Luc Reporter Cell Line - Jeko-1

The Jeko-1 cell line originated from the peripheral blood of a patient diagnosed with mantle cell lymphoma (MCL), making it a crucial resource for MCL research. Through meticulous characterization, Jeko-1 exhibited characteristic features of MCL, including the t(11;14)(q13;q32) translocation and overexpression of cyclin D1. This faithful representation of MCL pathophysiology positions Jeko-1 as an indispensable tool for unraveling the disease's etiology and exploring therapeutic strategies. The creation of the GFP/Luc reporter cell line involved transfecting Jeko-1 cells with plasmids encoding green fluorescent protein (GFP) and luciferase. This innovative modification enables dynamic visualization and quantification of cellular processes and drug responses both in vitro and in vivo. Such advancements not only offer unprecedented insights into the underlying biology of MCL but also facilitate the assessment of novel therapeutic interventions and their efficacy. The establishment of the Jeko-1 cell line marked a seminal milestone in MCL research, catalyzing deeper investigations into its molecular intricacies and therapeutic modalities. Subsequent advancements, exemplified by the creation of the GFP/Luc reporter cell line, have further expanded the utility of Jeko-1, providing a sophisticated platform for conducting intricate experiments and high-throughput drug screenings tailored specifically to the context of MCL.