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Rat Xpa cDNA Clone(NM_001106656.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR006407

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Gene Information

Cat. No. CDFR006407
Description NativeORF clone of Rattus norvegicus xeroderma pigmentosum, complementation group A (Xpa) as transfection-ready DNA NM_001106656.1
Product Type cDAN Clone
Gene Abbr Xpa
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene XPA
Background This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq, Aug 2017]
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