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Human XPA Knockdown Cell Line-HeLa

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Cat.No.
CSC-RK0014
Background
This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HeLa
Ship
Dry ice
Gene Information
Official Symbol
XPA
Synonyms
XPA; xeroderma pigmentosum, complementation group A; DNA repair protein complementing XP-A cells; XP1; XPAC; excision repair-controlling; xeroderma pigmentosum group A-complementing protein;
Gene ID
MIM
UniProt ID
P23025
Chromosome Location
9q22.3
Pathway
DNA Repair, organism-specific biosystem; Dual incision reaction in GG-NER, organism-specific biosystem; Formation of incision complex in GG-NER, organism-specific biosystem; Global Genomic NER (GG-NER), organism-specific biosystem; Nucleotide Excision Repair, organism-specific biosystem; Nucleotide excision repair, organism-specific biosystem; Nucleotide excision repair, conserved biosystem;
Function
damaged DNA binding; metal ion binding; nucleotide binding; protein binding; protein domain specific binding; protein homodimerization activity;

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