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Rat Vhl cDNA Clone(NM_052801.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR013031

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Gene Information

Cat. No. CDFR013031
Description NativeORF clone of Rattus norvegicus von Hippel-Lindau tumor suppressor (Vhl) as transfection-ready DNA NM_052801.1
Product Type cDAN Clone
Gene Abbr Vhl
Species Rat
Vector pCMV6Entry
Target Gene VHL
Background This gene encodes a component of a ubiquitination complex. The encoded protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. In addition to oxygen-related gene expression, this protein plays a role in many other cellular processes including cilia formation, cytokine signaling, regulation of senescence, and formation of the extracellular matrix. Variants of this gene are associated with von Hippel-Lindau syndrome, pheochromocytoma, erythrocytosis, renal cell carcinoma, and cerebellar hemangioblastoma. [provided by RefSeq, Jun 2022]
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