Transfected Stable Cell Lines
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Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : CDFR013031
| Cat. No. | CDFR013031 |
| Description | NativeORF clone of Rattus norvegicus von Hippel-Lindau tumor suppressor (Vhl) as transfection-ready DNA NM_052801.1 |
| Product Type | cDAN Clone |
| Gene Abbr | Vhl |
| Species | Rat |
| Vector | pCMV6Entry |
| Target Gene | VHL |
| Background | This gene encodes a component of a ubiquitination complex. The encoded protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. In addition to oxygen-related gene expression, this protein plays a role in many other cellular processes including cilia formation, cytokine signaling, regulation of senescence, and formation of the extracellular matrix. Variants of this gene are associated with von Hippel-Lindau syndrome, pheochromocytoma, erythrocytosis, renal cell carcinoma, and cerebellar hemangioblastoma. [provided by RefSeq, Jun 2022] |
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