Rat Vav1 cDNA Clone(NM_012759.2)

Name: Rat Vav1 cDNA Clone(NM_012759.2)
SKU: CDFR010616
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR010616

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Product Information

Gene Information

Cat. No.	CDFR010616
Description	NativeORF clone of Rattus norvegicus vav 1 guanine nucleotide exchange factor (Vav1) as transfection-ready DNA NM_012759.2
Product Type	cDAN Clone
Gene Abbr	Vav1
Species	Rat
Vector	pCMV6Entry

Target Gene

VAV1

Background

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

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