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Rat Trmt1 cDNA Clone(NM_001013870.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR002953

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Gene Information

Cat. No. CDFR002953
Description NativeORF clone of Rattus norvegicus TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae) (Trmt1) as transfection-ready DNA NM_001013870.1
Product Type cDAN Clone
Gene Abbr Trmt1
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene TRMT1
Background This gene encodes a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger motif, and an arginine/proline-rich region. Mutations in this gene have been implicated in autosomal recessive intellectual disorder (ARID). Alternative splicing results in multiple transcript variants encoding different isoforms. There is a pseudogene of this gene on the X chromosome. [provided by RefSeq, May 2017]
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