Mouse Trmt1 ORF clone (NM_001164560.1)

Name: Mouse Trmt1 ORF clone (NM_001164560.1)
SKU: CDCH095394
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCH095394

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Product Information

Gene Information

Cat. No.	CDCH095394
Description	Mus musculus TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae) (Trmt1), transcript variant 3, mRNA.
Product Type	ORF clone
Gene Abbr	Trmt1
Species	Mouse
ORF Size	1971bp
Format	purified plasmid
Vector	pDONR
Warning	Please note that the protein for this clone has been annotated or predicted in the UNIPROT database to have a signal peptide. Placing a tag at the N-terminus of this protein may result in loss of the signal peptide function.

Target Gene

TRMT1

Background

This gene encodes a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger motif, and an arginine/proline-rich region. Mutations in this gene have been implicated in autosomal recessive intellectual disorder (ARID). Alternative splicing results in multiple transcript variants encoding different isoforms. There is a pseudogene of this gene on the X chromosome. [provided by RefSeq, May 2017]

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