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Rat Tgif1 cDNA Clone(NM_001015020.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR003419

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Gene Information

Cat. No. CDFR003419
Description NativeORF clone of Rattus norvegicus TGFB-induced factor homeobox 1 (Tgif1) as transfection-ready DNA NM_001015020.1
Product Type cDAN Clone
Gene Abbr Tgif1
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene TGIF1
Background The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]
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