Mouse Tgif1 ORF Clone(NM_009372.3)

Name: Mouse Tgif1 ORF Clone(NM_009372.3)
SKU: CDCR247106
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR247106

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Product Information

Gene Information

Cat. No.	CDCR247106
Product Type	ORF Clone
Gene Abbr	Tgif1
Species	Mouse
Tag	C-terminal TurboGFP
ORF Size	818 bp
Size	10 ug
Vector	pCMV6-AC-GFP

Target Gene

TGIF1

Background

The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]

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