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Rat Tgfbr2 cDNA Clone(NM_031132.3)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR012602

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Gene Information

Cat. No. CDFR012602
Description NativeORF clone of Rattus norvegicus transforming growth factor, beta receptor II (Tgfbr2) as transfection-ready DNA NM_031132.3
Product Type cDAN Clone
Gene Abbr Tgfbr2
Species Rat
Vector pCMV6Entry
Target Gene TGFBR2
Background The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]
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