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Rat Tdg ORF Clone(NM_053729.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR380382

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Product Information

Gene Information

Cat. No. CDCR380382
Product Type ORF Clone
Gene Abbr Tdg
Species Rat
Tag C-terminal Myc-DDK
ORF Size 1161 bp
Vector pCMV6-Entry
Target Gene TDG
Background The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]
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