Rat Tap2 cDNA Clone(NM_032056.3)

Name: Rat Tap2 cDNA Clone(NM_032056.3)
SKU: CDFR012994
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR012994

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Product Information

Gene Information

Cat. No.	CDFR012994
Description	NativeORF clone of Rattus norvegicus transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) (Tap2) as transfection-ready DNA NM_032056.3
Product Type	cDAN Clone
Gene Abbr	Tap2
Species	Rat
Vector	pCMV6Entry

Target Gene

TAP2

Background

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014]

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