Rat Tagln cDNA Clone(NM_031549.2)

Name: Rat Tagln cDNA Clone(NM_031549.2)
SKU: CDFR012707
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR012707

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Product Information

Gene Information

Cat. No.	CDFR012707
Description	NativeORF clone of Rattus norvegicus transgelin (Tagln) as transfection-ready DNA NM_031549.2
Product Type	cDAN Clone
Gene Abbr	Tagln
Species	Rat
Vector	pCMV6Entry

Target Gene

TAGLN

Background

This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization. [provided by RefSeq, Aug 2017]

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