Mouse TAGLN ORF clone(NM_011526.5)

Name: Mouse TAGLN ORF clone(NM_011526.5)
SKU: CDCH016515
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCH016515

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Product Information

Gene Information

Cat. No.	CDCH016515
Product Type	ORF clone
Gene Abbr	TAGLN
Species	Mouse
Host Cell	Bacterial
Source	Bacterial
ORF Size	1586bp
Size	1ug
Format	Clear Liquid
Vector	pORF
Buffer	10mM Tris-HCI, 1mM EDTA, pH8.0
Warning	pORF-mTagln ORF Vector is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information.
Storage	1 year when stored at -20°C or lower in a non-frost free freezer.

Target Gene

TAGLN

Background

This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization. [provided by RefSeq, Aug 2017]

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