Rat TNFSF11 ORF clone(NM_057149.1)

Name: Rat TNFSF11 ORF clone(NM_057149.1)
SKU: CDCL186566
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCL186566

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Product Information

Gene Information

Cat. No.	CDCL186566
Description	ORF Clone of Rattus norvegicus tumor necrosis factor (ligand) superfamily, member 11 DNA.
Product Type	ORF clone
Gene Abbr	TNFSF11
Species	Rat
ORF Size	957bp
Vector	pGEM-T
Warning	This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Storage	store at -20°C

Target Gene

TNFSF11

Background

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]

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