Rat Skp2 ORF Clone(NM_001106416.2)

Name: Rat Skp2 ORF Clone(NM_001106416.2)
SKU: CDCR373215
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR373215

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Product Information

Gene Information

Cat. No.	CDCR373215
Product Type	ORF Clone
Gene Abbr	Skp2
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	1272 bp
Vector	pCMV6-Entry

Target Gene

SKP2

Background

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]

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