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Rat Setd2 cDNA Clone(NM_001108189.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR007832

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Gene Information

Cat. No. CDFR007832
Description NativeORF clone of Rattus norvegicus SET domain containing 2 (Setd2) as transfection-ready DNA NM_001108189.1
Product Type cDAN Clone
Gene Abbr Setd2
Species Rat
Vector pCMV6Entry
Target Gene SETD2
Background Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]
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