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Mouse Setd2 ORF Clone(NM_001081340.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR234821

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Product Information

Gene Information

Cat. No. CDCR234821
Product Type ORF Clone
Gene Abbr Setd2
Species Mouse
Tag C-terminal TurboGFP
ORF Size 7614 bp
Size 10 ug
Vector pCMV6-AC-GFP
Target Gene SETD2
Background Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]
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