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Rat Sesn1 cDNA Clone(NM_001106396.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR006135

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Gene Information

Cat. No. CDFR006135
Description NativeORF clone of Rattus norvegicus sestrin 1 (Sesn1) as transfection-ready DNA NM_001106396.1
Product Type cDAN Clone
Gene Abbr Sesn1
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene SESN1
Background This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
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