Mouse Sesn1 ORF clone (NM_001162908.1)

Name: Mouse Sesn1 ORF clone (NM_001162908.1)
SKU: CDCH078966
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCH078966

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Product Information

Gene Information

Cat. No.	CDCH078966
Description	Mus musculus sestrin 1 (Sesn1), transcript variant 1, mRNA.
Product Type	ORF clone
Gene Abbr	Sesn1
Species	Mouse
ORF Size	1656bp
Format	purified plasmid
Vector	pDONR
Warning	Please note that the protein for this clone has been annotated or predicted in the UNIPROT database to have a signal peptide. Placing a tag at the N-terminus of this protein may result in loss of the signal peptide function.

Target Gene

SESN1

Background

This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

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