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Rat Rrm2b ORF Clone(NM_001130543.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR376474

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Gene Information

Cat. No. CDCR376474
Product Type ORF Clone
Gene Abbr Rrm2b
Species Rat
Tag C-terminal Myc-DDK
ORF Size 1056 bp
Vector pCMV6-Entry
Target Gene RRM2B
Background This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
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