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Rat Rnf217 cDNA Clone(NM_001106204.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR005963

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Gene Information

Cat. No. CDFR005963
Description NativeORF clone of Rattus norvegicus ring finger protein 217 (Rnf217) as transfection-ready DNA NM_001106204.1
Product Type cDAN Clone
Gene Abbr Rnf217
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene RNF217
Background This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
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