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Mouse Rnf217 cDNA Clone(NM_001146349.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFG019822

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Gene Information

Cat. No. CDFG019822
Product Type cDNA clone
Gene Abbr Rnf217
Species Mouse
ORF Size 1548bp
Size 10 ug
Vector pCMV6Entry
Target Gene RNF217
Background This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
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