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Rat Pstpip1 cDNA Clone(NM_001106824.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR006552

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Gene Information

Cat. No. CDFR006552
Description NativeORF clone of Rattus norvegicus proline-serine-threonine phosphatase-interacting protein 1 (Pstpip1) as transfection-ready DNA NM_001106824.2
Product Type cDAN Clone
Gene Abbr Pstpip1
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene PSTPIP1
Background This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response. [provided by RefSeq, Mar 2016]
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