Mouse Pstpip1 ORF Clone(NM_011193.2)

Name: Mouse Pstpip1 ORF Clone(NM_011193.2)
SKU: CDCR250263
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR250263

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Product Information

Gene Information

Cat. No.	CDCR250263
Product Type	ORF Clone
Gene Abbr	Pstpip1
Species	Mouse
Tag	C-terminal TurboGFP
ORF Size	1248 bp
Size	10 ug
Vector	pCMV6-AC-GFP

Target Gene

PSTPIP1

Background

This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response. [provided by RefSeq, Mar 2016]

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