Rat Psap cDNA Clone(NM_013013.2)

Name: Rat Psap cDNA Clone(NM_013013.2)
SKU: CDFR010819
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR010819

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Product Information

Gene Information

Cat. No.	CDFR010819
Description	NativeORF clone of Rattus norvegicus prosaposin (Psap) as transfection-ready DNA NM_013013.2
Product Type	cDAN Clone
Gene Abbr	Psap
Species	Rat
Vector	pCMV6Entry

Target Gene

PSAP

Background

This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

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