Mouse Psap ORF clone (NM_001146124.1)

Name: Mouse Psap ORF clone (NM_001146124.1)
SKU: CDCH068750
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCH068750

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Product Information

Gene Information

Cat. No.	CDCH068750
Description	Mus musculus prosaposin (Psap), transcript variant 6, mRNA.
Product Type	ORF clone
Gene Abbr	Psap
Species	Mouse
ORF Size	1656bp
Format	purified plasmid
Vector	pDONR
Warning	Please note that the protein for this clone has been annotated or predicted in the UNIPROT database to have a signal peptide. Placing a tag at the N-terminus of this protein may result in loss of the signal peptide function.

Target Gene

PSAP

Background

This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

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