Rat Prkg1 ORF Clone(NM_001105731.2)

Name: Rat Prkg1 ORF Clone(NM_001105731.2)
SKU: CDCR372513
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR372513

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Product Information

Gene Information

Cat. No.	CDCR372513
Product Type	ORF Clone
Gene Abbr	Prkg1
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	2016 bp
Vector	pCMV6-Entry

Target Gene

PRKG1

Background

Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]

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