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Rat Prf1 cDNA Clone(NM_017330.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR011044

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Gene Information

Cat. No. CDFR011044
Description NativeORF clone of Rattus norvegicus perforin 1 (pore forming protein) (Prf1) as transfection-ready DNA NM_017330.2
Product Type cDAN Clone
Gene Abbr Prf1
Species Rat
Vector pCMV6Entry
Target Gene PRF1
Background This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017]
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