Transfected Stable Cell Lines
Reliable | High-Performance | Wide Rage
Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : CDFR011044
| Cat. No. | CDFR011044 |
| Description | NativeORF clone of Rattus norvegicus perforin 1 (pore forming protein) (Prf1) as transfection-ready DNA NM_017330.2 |
| Product Type | cDAN Clone |
| Gene Abbr | Prf1 |
| Species | Rat |
| Vector | pCMV6Entry |
| Target Gene | PRF1 |
| Background | This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017] |
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