Rat Prdm9 cDNA Clone(NM_001108903.2)

Name: Rat Prdm9 cDNA Clone(NM_001108903.2)
SKU: CDFR008469
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR008469

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Product Information

Gene Information

Cat. No.	CDFR008469
Description	NativeORF clone of Rattus norvegicus PR domain containing 9 (Prdm9) as transfection-ready DNA NM_001108903.2
Product Type	cDAN Clone
Gene Abbr	Prdm9
Species	Rat
Vector	pCMV6Entry

Target Gene

PRDM9

Background

The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described. [provided by RefSeq, Jul 2015]

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