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Mouse Prdm9 cDNA Clone(NM_144809.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFL010741

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Product Information

Gene Information

Cat. No. CDFL010741
Product Type cDNA clone
Gene Abbr Prdm9
Species Mouse
Size 10 ug
Vector pCMV6Entry
Target Gene PRDM9
Background The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described. [provided by RefSeq, Jul 2015]
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