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Rat Plod2 cDNA Clone(NM_001142915.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR010299

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Gene Information

Cat. No. CDFR010299
Description NativeORF clone of Rattus norvegicus procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 (Plod2), transcript variant 2 as transfection-ready DNA NM_001142915.1
Product Type cDAN Clone
Gene Abbr Plod2
Species Rat
Vector pCMV6Entry
Target Gene PLOD2
Background The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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