Rat Pdcd6ip cDNA Clone(NM_001029910.2)

Name: Rat Pdcd6ip cDNA Clone(NM_001029910.2)
SKU: CDFR004127
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR004127

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Product Information

Gene Information

Cat. No.	CDFR004127
Description	NativeORF clone of Rattus norvegicus programmed cell death 6 interacting protein (Pdcd6ip) as transfection-ready DNA NM_001029910.2
Product Type	cDAN Clone
Gene Abbr	Pdcd6ip
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

PDCD6IP

Background

This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012]

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