Mouse PDCD6IP ORF clone(NM_011052.2)

Name: Mouse PDCD6IP ORF clone(NM_011052.2)
SKU: CDCH018357
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCH018357

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Product Information

Gene Information

Cat. No.	CDCH018357
Product Type	ORF clone
Gene Abbr	PDCD6IP
Species	Mouse
Host Cell	Bacterial
Source	Bacterial
ORF Size	5961bp
Size	1ug
Format	Clear Liquid
Vector	pORF
Buffer	10mM Tris-HCI, 1mM EDTA, pH8.0
Warning	pORF-mPdcd6ip ORF Vector is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information.
Storage	1 year when stored at -20°C or lower in a non-frost free freezer.

Target Gene

PDCD6IP

Background

This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012]

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