Rat Nr3c1 ORF Clone(NM_012576.2)

Name: Rat Nr3c1 ORF Clone(NM_012576.2)
SKU: CDCR377312
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR377312

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Product Information

Gene Information

Cat. No.	CDCR377312
Product Type	ORF Clone
Gene Abbr	Nr3c1
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	2385 bp
Vector	pCMV6-Entry

Target Gene

NR3C1

Background

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]

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