Rat Nod1 cDNA Clone(NM_001109236.1)

Name: Rat Nod1 cDNA Clone(NM_001109236.1)
SKU: CDFR008775
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR008775

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Product Information

Gene Information

Cat. No.	CDFR008775
Description	NativeORF clone of Rattus norvegicus nucleotide-binding oligomerization domain containing 1 (Nod1) as transfection-ready DNA NM_001109236.1
Product Type	cDAN Clone
Gene Abbr	Nod1
Species	Rat
Vector	pCMV6Entry

Target Gene

NOD1

Background

This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017]

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