Rat Ncstn cDNA Clone(NM_174864.3)

Name: Rat Ncstn cDNA Clone(NM_174864.3)
SKU: CDFR014832
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR014832

Inquire for Price

Product Information

Gene Information

Cat. No.	CDFR014832
Description	NativeORF clone of Rattus norvegicus nicastrin (Ncstn) as transfection-ready DNA NM_174864.3
Product Type	cDAN Clone
Gene Abbr	Ncstn
Species	Rat
Vector	pCMV6Entry

Target Gene

NCSTN

Background

This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]

Quick Inquiry

Q & A

Customer Reviews

Ask a Question

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

Question *

Name

Country *

Email *

Write a Review

Write a review of your use of Biogene products and services in your research. Your review can help your fellow researchers make informed purchasing decisions.

Product Name *

Catalog Name *

Rating

Needs improvement

Satisfaction

General satisfaction

Very satisfaction

Product Review Title *

Summary *