Rat Mtor cDNA Clone(NM_019906.1)

Name: Rat Mtor cDNA Clone(NM_019906.1)
SKU: CDFR011632
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR011632

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Product Information

Gene Information

Cat. No.	CDFR011632
Description	NativeORF clone of Rattus norvegicus FK506 binding protein 12-rapamycin associated protein 1 (Frap1) as transfection-ready DNA NM_019906.1
Product Type	cDAN Clone
Gene Abbr	Mtor
Species	Rat
Vector	pCMV6Entry

Target Gene

MTOR

Background

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Aug 2020]

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