Mouse Mtor ORF Clone(NM_020009.2)

Name: Mouse Mtor ORF Clone(NM_020009.2)
SKU: CDCR254695
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR254695

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Product Information

Gene Information

Cat. No.	CDCR254695
Product Type	ORF Clone
Gene Abbr	Mtor
Species	Mouse
Tag	C-terminal Myc-DDK
ORF Size	7649 bp
Size	10 ug
Vector	pCMV6-Entry

Target Gene

MTOR

Background

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Aug 2020]

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