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Rat Mkks cDNA Clone(NM_001008353.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR001815

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Gene Information

Cat. No. CDFR001815
Description NativeORF clone of Rattus norvegicus McKusick-Kaufman syndrome (Mkks) as transfection-ready DNA NM_001008353.1
Product Type cDAN Clone
Gene Abbr Mkks
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene MKKS
Background This gene encodes a protein which shares sequence similarity with other members of the type II chaperonin family. The encoded protein is a centrosome-shuttling protein and plays an important role in cytokinesis. This protein also interacts with other type II chaperonin members to form a complex known as the BBSome, which involves ciliary membrane biogenesis. This protein is encoded by a downstream open reading frame (dORF). Several upstream open reading frames (uORFs) have been identified, which repress the translation of the dORF, and two of which can encode small mitochondrial membrane proteins. Mutations in this gene have been observed in patients with Bardet-Biedl syndrome type 6, also known as McKusick-Kaufman syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2023]
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