Transfected Stable Cell Lines
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Cat. No. : CDCL132845
| Cat. No. | CDCL132845 |
| Description | Mus musculus McKusick-Kaufman syndrome protein (Mkks), transcript variant 2, mRNA. |
| Product Type | ORF clone |
| Gene Abbr | Mkks |
| Species | Mouse |
| ORF Size | 1713bp |
| Format | purified plasmid |
| Vector | pDONR |
| Warning | Please note that the protein for this clone has been annotated or predicted in the UNIPROT database to have a signal peptide. Placing a tag at the N-terminus of this protein may result in loss of the signal peptide function. |
| Target Gene | MKKS |
| Background | This gene encodes a protein which shares sequence similarity with other members of the type II chaperonin family. The encoded protein is a centrosome-shuttling protein and plays an important role in cytokinesis. This protein also interacts with other type II chaperonin members to form a complex known as the BBSome, which involves ciliary membrane biogenesis. This protein is encoded by a downstream open reading frame (dORF). Several upstream open reading frames (uORFs) have been identified, which repress the translation of the dORF, and two of which can encode small mitochondrial membrane proteins. Mutations in this gene have been observed in patients with Bardet-Biedl syndrome type 6, also known as McKusick-Kaufman syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2023] |
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