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Rat Mbtps1 ORF Clone(NM_053569.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR380329

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Gene Information

Cat. No. CDCR380329
Product Type ORF Clone
Gene Abbr Mbtps1
Species Rat
Tag C-terminal Myc-DDK
ORF Size 3159 bp
Vector pCMV6-Entry
Target Gene MBTPS1
Background This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014]
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